On the west side of the island, just a short distance from the monastery of Philanthropinon, is the monastery of Diliou. Founders of the monastery are members of the profound family of Stratigopoulou who settled in Ioannina after the occupation of Constantinople by the Crusaders in 1204. The nickname Diliou derives from the sponsorship of a wealthy citizen of Ioannina, G. Diliou, who financed the repairing of the monastery in 1700.

It was also named Despoton Monastery because in the 16th century housed the famous school of Despots, founder of which was the Bishop of Epirus, Michail Angelos. In Diliou Monastery we can admire the buildings of the catholic (-13th- 11th century) and Igoumeneion, a later building dating from the 16th century. The monastery, basilica with saddle roof is consisted of the narthex, the nave and the sanctuary. Decorated with particularly remarkable frescoes which date back to 1542/43, while at the same venue a remarkable wooden temple is located, a project made by mainland workshops at the end of the 18th -19th century. Among them stands out the image of the enthroned Christ as the Great High Priest, a 16th century work and the image of Virgin and Child dating at 1783.